HGH 191AA – Premium Research Peptide

What Is HGH 191AA?

HGH 191AA is a synthetic recombinant human growth hormone (somatropin) comprising the full 191-amino-acid sequence identical to endogenous pituitary-derived growth hormone. This full-length peptide serves as a foundational tool in research exploring the growth hormone axis, body composition, and metabolic regulation.

The 191AA designation refers to the exact amino acid count of native human growth hormone, distinguishing it from truncated variants or fragments. As a complete 191-amino-acid single-chain polypeptide with a molecular weight of approximately 22 kDa, this peptide engages the growth hormone receptor (GHR) to initiate intracellular signaling cascades, including the JAK/STAT, PI3K/AKT, and MAPK/ERK pathways. These signaling events mediate a wide range of biological effects, from promoting linear growth to modulating glucose and lipid metabolism.

Research on the C-terminal region of HGH 191AA has identified specific sequences, such as hGH(177-191), that promote glycogen synthase conversion in muscle tissue. Additionally, fragments like hGH(176-191) are studied for their lipolytic (fat-burning) activity without activating the GHR or elevating IGF-1 levels.

For researchers investigating the growth hormone axis, metabolic disorders, or the effects of growth hormone on muscle and adipose tissue, HGH 191AA represents the full-length reference standard.

---

Product Specifications

---

Research Applications

Growth Hormone Axis Biology

The full-length structure of this compound allows researchers to investigate receptor binding, intracellular signaling, and downstream effects on gene expression and protein synthesis. Growth hormone activates the Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathway, with JAK2 activation being required for GH-mediated activation of STAT1, STAT3, and STAT5.

Body Composition and Metabolism

Research into HGH 191AA has focused on its anabolic effects on lean body mass and its lipolytic effects on adipose tissue. The peptide’s influence on glycogen synthase activity, particularly through its C-terminal fragments, provides insight into glucose metabolism and insulin sensitivity.

Endocrine and Metabolic Disorders

As the full-length reference standard, HGH 191AA is essential for studies on growth hormone deficiency, acromegaly, and metabolic syndrome. Its interactions with both somatogenic and lactogenic receptors are of particular interest. The human growth hormone (GH) is a 191-amino acid polypeptide produced by the pituitary gland that has widespread effects on many organs and tissues either directly via growth hormone receptors or indirectly via production of insulin-like growth factor-1 (IGF-1) by the liver.

Fragment and Analog Development

Researchers use this peptide as the parent molecule for developing and studying smaller fragments such as hGH(176-191) and hGH(177-191), which retain specific biological activities without full receptor activation. The synthetic peptide hGH 177-191, corresponding to the last 15 residues at the carboxyl terminus of human pituitary growth hormone, promotes the conversion of glycogen synthase a to glycogen synthase b in muscle.

---

Quality and Purity

Each batch undergoes rigorous quality control testing to ensure:

• ≥97% purity verified by HPLC

• Correct molecular weight confirmed by mass spectrometry

• Consistent amino acid sequence validated by peptide mapping

Certificates of Analysis (COA) are available upon request, providing full transparency for research applications.

---

Frequently Asked Questions

What is this peptide?

HGH 191AA is recombinant human growth hormone (somatropin) with the complete 191-amino-acid sequence identical to endogenous pituitary-derived growth hormone. It is used as a research tool to study the growth hormone axis and metabolic regulation.

How does this differ from growth hormone fragments?

Full-length HGH 191AA activates the growth hormone receptor and initiates the IGF-1 axis, while smaller fragments like hGH(176-191) may retain specific activities such as lipolysis without full receptor activation.

What is the molecular weight?

This peptide has a molecular weight of approximately 22 kDa.

What purity level can I expect?

Our product is provided at ≥97% purity, verified by HPLC.

How should it be stored?

The peptide should be stored at -20°C for long-term stability. Lyophilised powder should be reconstituted according to standard laboratory protocols.

Is it suitable for clinical use?

No. This product is supplied for research purposes only and is not intended for human consumption or clinical application.

---

References

• PubMed: Regulation of glycogen synthase activity in muscle by a C-terminal part sequence of human growth hormone – hGH 177-191 promotes glycogen synthase conversion in muscle

• PubMed: A recombinant-DNA-derived modification of human growth hormone (hGH44-191) with enhanced diabetogenic activity – hGH44-191 fragment with enhanced diabetogenic activity

• PubMed: Human growth hormone (hGH)-(44-191), a reportedly diabetogenic fragment of hGH, circulates in human blood – hGH44-191 fragment circulating in human blood

• PubMed: The Growth Hormone Receptor: Mechanism of Receptor Activation, Cell Signaling, and Physiological Aspects – JAK-STAT signaling pathway in GH receptor activation

• PubMed: Growth hormone signaling and clinical implications: from molecular to therapeutic perspectives – JAK-STAT, PI3K/AKT, and MAPK signaling pathways

• NIH DailyMed: Nutropin® somatropin (rDNA origin) for injection – 191 amino acid residues, molecular weight 22,125 daltons

• NIH MeSH: Human Growth Hormone – 191-amino acid polypeptide hormone

• FDA: TEV-TROPIN® somatropin (rDNA origin) for injection – 191 amino acid residues, molecular weight ~22,124 daltons

• Peptide Protocol Wiki: HGH 191AA – Molecular structure and signaling pathways

• CertaPeptides: HGH 191AA – ≥98% purity, recombinant human growth hormone

---

Conclusion

HGH 191AA is the full-length recombinant human growth hormone standard for researchers investigating the growth hormone axis, metabolic regulation, and body composition. With its complete 191-amino-acid sequence identical to endogenous growth hormone, this peptide enables studies on receptor binding, intracellular signaling, and the diverse physiological effects of growth hormone.

For researchers requiring a reliable, high-purity reference standard for growth hormone research, HGH 191AA provides the foundation for meaningful scientific inquiry.

---

Ready to Advance Your Research?

Order premium HGH 191AA for your research today. Contact our team for COA requests or technical inquiries.

Shop Now

Contact Our Research Team